Paleolithic diets, based on the diet of our hunter-gatherer ancestors, have been gaining popularity in recent years.
- A recent study in mouse models highlights potential health risks associated with these high-protein diets.
- Mice fed a high-protein Paleolithic diet had high levels of ammonium in their blood, a waste product of protein breakdown.
- This can lead to liver and neurological toxicity. In the most severe cases, it can even lead to coma and death.
Promoted to aid weight loss, improve metabolic health and reduce the risk of chronic diseases, they are characterized by a high consumption of animal protein, fruits, vegetables and nuts, while excluding grains, legumes and dairy products.
However, a recent study in mouse models highlights potential health risks associated with these high-protein diets. Published in the journal ScienceDailythe study found that mice fed a high-protein Paleolithic diet had high levels of ammonium in their blood, a waste product of protein breakdown.
Paleolithic diet: beware of ammonium accumulation in the blood
The accumulation of ammonium in the blood can lead to liver and neurological toxicity. In the most severe cases, it can even lead to coma and death. The researchers explain that the increase in ammonium levels observed in mice is linked to the high consumption of animal proteins in the Paleolithic diet.
This study raises concerns about the long-term safety of high-protein Paleolithic diets, particularly in people at risk for liver or kidney disease. Further research is needed to determine the precise effects of these diets on human health and identify populations that may be at risk.
It is important to note that this study was conducted in animal models and its results cannot be directly applied to humans. Rigorous clinical studies are needed to confirm the observations made in mice and assess the potential risks and benefits of Paleolithic diets for human health.
Consult a doctor before starting a Paleolithic diet
In the meantime, it is recommended that you consult a healthcare professional before starting a Paleolithic diet, especially if you have any pre-existing health conditions. A healthcare professional can help you assess the potential risks and benefits of this type of diet and provide you with an eating plan that is tailored to your individual needs.
It’s also important to remember that not all diets are right for everyone. An individualized approach is key to finding a healthy, sustainable eating pattern that supports your overall well-being.