June 30, 2016.
The origin of our migraines has finally been discovered! It was a long struggle but the result is finally here: published by The International Headache Genetics Consortium (IHGC), the study proves that migraines are mainly linked to a vascular or neurological problem.
A problem with the blood supply
The study conducted by the IHGC brings together a sample of 60,000 people, drawn from 22 genome-wide studies carried out by associations. The groups are made up of more than 12 countries that help with research. The first time, 28 genomic regions were studied, compared to 38 for this new study.
According to IHGC Director Aarno Palotie, “ In this latest large-scale study, dozens of new genetic risk factors were discovered “. He pursues : ” Because all of these variants slightly alter the risk of disease, the effect could only be seen when this large amount of samples became available. “.
Research proves that vascular and muscle problems play an important role in the development of migraines. While these genes are newly associated with migraine, they have also been linked to vascular disease, smooth muscle contraction, regulation of vascular tone, and artery function.
Results that help inform research for future treatments
The researchers agree that the insufficient number of tissue samples included in the new research may have skewed the results, as previous studies have found significant links between genes in brain tissue and migraines. Here, this is not the case.
Researchers also found evidence that migraines may be linked to ion channels in the nervous system, which help transmit neural signals, which is a potential area for further study. The team shared their data, to help identify links between migraines and certain genomes. The researchers were keen to emphasize the benefits of working together.
According to John Anker Zwart of the University of Oslo Hospital in Norway, “cGenetic results are the first concrete step towards the personalized development of evidence-based treatments for this very complex disease “. The objective of this research and of potential future studies is to lead to more effective and more personalized treatments for people who suffer from migraines.
Read also: 5 sleep tips to reduce migraines
