the premenstrual syndrome is a disorder that affects many women in the 7-10 days before their rules. Changes in mood, irritability, tight breasts, swollen and painful belly, migraines: the manifestations of PMS are numerous.
But a small number of women suffer from a more severe form of PMS, called premenstrual dysphoric disorder, with marked anxiety and depressed mood.
Hypersensitivity to sex hormones
In a new study, researchers found that these women exhibited abnormal expression of genes that respond to sex hormones. This genetic defect increases their sensitivity to progesterone and estrogen, which is thought to contribute to this acute form of PMS.
To reach these conclusions, researchers at the National Institute of Mental Health (NIMH) looked at the gene expression of women aged 18 to 48 with premenstrual syndrome. They thus obtained proof that premenstrual dysphoric disorder is a defect in the cellular response to sex hormones.
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