Hormones (whether they are secreted naturally or whether they are synthetic) have an impact on morale, this is nothing new. And a recent GIS Epi-Phare studypublished in the journal JAMA Network, relating to hormonal IUDs, reminds us of this. Certain intrauterine devices would be associated with an increased risk of depressive states.As with all hormonal birth control, use of a levonorgestrel intrauterine device (IUD, also called IUD) may be associated with a low risk of depression or mood disorders (depressed mood)“, indicates a note of theANSM.
Thanks to reimbursement data provided by Health Insurance, it has been shown that some women carrying IUDs were treated more with antidepressants within two years after IUD insertion than others. Two products are mainly singled out: Mirena and Donasert with the highest dose of levonorgestrel, up to 52mg.
Mood to watch
Depressive syndromes would be slightly higher than for IUDs with less of this hormone, Kyleena and jaydess (at 19.5mg): the rate of taking antidepressants goes from 3.6% to 4% of women. This corresponds to an increase of 13%. This is not an unknown side effect because it was already mentioned in the instructions for use.
What to do if you have a hormonal IUD? The ANSM calls on women who wear them not to rush and to carefully assess the benefits and disadvantages of the device, especially for women who suffer from endometriosis or menorrhagia. It is not no need to remove them, but you have to be attentive to the mood disorders that can occur. Furthermore, the Agency hopes that this study will enable healthcare professionals to warn patients who may be given these devices.
Sources:
- IUDs containing the most hormone present a greater risk of depressive disorders, ANSM, 14 February 2023
- Association between levonorgestrel intrauterine devices and subsequent use of psychotropic drugs in France, EPI-PHARE, 3 January 2023
