Step by step, will researchers succeed in combating obesity? Inserm researchers have found the solution to create large quantities of brown adipocyte cells, according to the results of a study published in the journal Nature. A new therapeutic voice to care for people obese ? By transplanting these cells in overweight people, the researchers hope to increase energy expenditure and therefore calories, thus promoting weight loss. Indeed, brown adipocytes have the ability to consume energy, while whites store it.
A new therapeutic option to treat the obese
In vitro, the researchers used human IPS cells (adult cells reprogrammed into cells capable of giving back any kind of cells in the body). They were able to produce “good fat” cells in large quantities.
Once this phase is completed, the researchers hope to be able to conduct clinical trials and test these brown cells in humans to fight obesity.
“The goal is to show that by transplanting these well-differentiated human brown cells into an obese animal, the metabolic parameters associated with obesity improve and that there is a therapeutic effect. In mice, it works.” , explains Christian Dani, responsible for this work. “Previous work has shown that transplanting rodent brown adipocytes to another obese rodent regresses its disease.” They hope of course then to test the strategy in humans, but “this can only be achieved after preclinical tests conducted in animal models, and by partnering with doctors who will help us develop this approach”.
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