A recent study conducted on patients with mastocytosis reveals that some depressions would be linked to the overactivation of immune cells called mast cells. A new avenue to explore in the understanding the illness of depression and to be able to help these depressive patients resistant to conventional antidepressants.
This study was conducted in Parisian hospitals Necker and Sainte-Anne, in patients with mastocytosis... But why then study these patients, to know more about the depression ?
Quite simply, because many studies suspect the inflammatory track in the depression. But also because 50% of patients with mastocytosis suffer from depression.
Two conclusions emerge from this study:
> The most depressed would have lower blood levels of tryptophan.
> The patients with mastocytosis would have lower blood levels of serotonin and higher levels of neurotoxic tryptophan derivatives.
A new one therapeutic approach could therefore emerge for these people with depression, especially those for whom antidepressants classics hardly work.
source: Inserm
