August 3, 2004 – The effectiveness of anti-inflammatory ointments and gels for osteoarthritis, sold by prescription, is limited in time, according to a study which has just appeared in the British Medical Journal1.
An analysis of clinical trials of topical nonsteroidal anti-inflammatory drugs (topical NSAIDs), such as odorless rheumatism creams sold by prescription, shows that these ointments cannot be considered a valid long-term treatment to alleviate pain associated with osteoarthritis.
In particular, the researchers looked at 13 clinical trials carried out over the past 40 years. In each study analyzed, topical NSAIDs were measured against either a placebo or an NSAID taken orally, for four weeks or less.
In general, the efficacy of the topical preparation was shown to be superior to placebo only during the first two weeks. Subsequently, participants in the group using topical NSAIDs did not experience a greater reduction in pain and stiffness in the joints than those taking the placebo. An identical result was observed with regard to the improvement of the functional capacity of the aching joints.
The use of ointments or gels to treat osteoarthritis pain has enjoyed tremendous popularity for decades, but their effectiveness has often been questioned. They are an alternative solution for people who suffer from side effects, such as stomach upset, caused by oral intake of NSAIDs that can be obtained without a prescription.
Currently, topical NSAIDs are generally recommended by doctors as a treatment for osteoarthritis. The authors of this meta-analysis propose a review of medical opinions on this subject. However, it must be recognized that clinical studies are conflicting with regard to topical NSAIDs. Several studies have concluded in the past that topical NSAIDs are as effective as those taken orally. In addition, very few clinical trials lasting longer than two weeks have been conducted. This is why the authors of the analysis indicate the need to carry out studies over several weeks, or even months, in order to determine the real curative significance of this remedy.
Osteoarthritis is the most common form of arthritis and occurs after the age of 45. In Canada, three million people suffer from it.
Marie france Coutu – PasseportSanté.net
1 Lin J, et al, Efficacy of topical non-steroidal anti-inflammatory drugs in the treatment of osteoarthritis: meta-analysis of randomized controlled trials, British Medical Journal, 2004 (Accessed August 3, 2004). http://bmj.bmjjournals.com/cgi/reprint/bmj.38159.639028.7C
