From the age of 30, our muscle mass begins to decrease. To remedy this, American scientists have increased the regeneration of muscle cells in mice by activating precursors in the muscle cells.
- Muscle mass begins to decline from the age of 30
- Molecular Compounds Used in Stem Cell Growth May Accelerate Muscle Tissue Regeneration
The older we get, the more our muscle mass volume is likely to decrease, which in seniors can lead to disability. To slow down this decrease in muscle capacity (known as sarcopenia), American scientists at the Salk Institute have been looking for ways to speed up the regeneration of muscle tissue, using a combination of molecular compounds commonly used in cell research. strains.
Published on May 25 in the magazine Nature Communications, their researchand demonstrate how Use of these compounds can increase muscle cell regeneration in mice by activating muscle cell precursors, called myogenic progenitors.
In this study, the team used two different mouse models to identify changes specific to muscle stem cells. The researchers voluntarily selected younger mice in order to analyze the effects of the factors, independent of age.
Stimulate the regeneration of muscle tissue
“Our study highlights specific factors capable of accelerating muscle regeneration and reveals the mechanism by which this occurred,” says Juan Carlos Izpisua Belmonte, professor at the Salk Institute and principal investigator.
Although further work is needed before this approach can be applied in humans, the research provides insight into the underlying mechanisms related to muscle regeneration and growth. A hope to help athletes maintain their performance, but also seniors, whose muscle tissue could regenerate more effectively.
Scientists are also investigating other ways to rejuvenate cells, including using mRNA and genetic engineering. These techniques could eventually lead to new approaches to stimulate the regeneration of tissues and organs.
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