This flagship ingredient of food supplements has been available for 25 years as capsules and tablets. It is a natural patented extract from the bark of the Landes maritime pine which has been the subject of no less than 300 publications and 130 clinical studies. Antioxidant, anti-inflammatory, fifty times more powerful than Vitamin E and twenty times more than the vitamin C, it acts as well on the dilation of the vessels as on the regeneration of collagen and hyaluronic acid. It thus improves blood circulation, strengthens the immune system, preserves vision, boosts energy, relieves joint pain and premenstrual syndrome. It also acts on the skin, to the point that several cosmetic brands (La Roche-Posay, Clarins) have incorporated it into the composition of certain anti-aging treatments. More than 700 products worldwide use Pycnogenol in their composition, including many food supplements. No side effects have, to date, been reported in nearly a hundred clinical studies.