Vaccinated people, hospitalized because of Covid-19, generally present more comorbidities.
- In this study, a vaccination schedule is considered complete when a person has received two doses or one dose and one infection, as the third dose was not recommended until September 2021.
- The authors emphasize the very low frequency of cases of hospitalization and death for Covid-19 in this sample of vaccinated population.
Vaccination offers protection against the risk of serious forms of Covid-19. But it is not infallible: among fully vaccinated people, some will have to be hospitalized after infection with the virus. A study d’Epi-phare, a structure that associates Medicare and the National Medicines Agency (ANSM), looked at the risk factors linked to these serious forms in vaccinated people. “Vaccines have major efficacy (around 90%) in preventing severe forms of COVID-19, but the question arises of a better understanding of the residual risk factors of certain groups of the population.specify the authors in the preamble.
#Covid19 | @EPIPHAREscientific interest group in the epidemiology of products of #healthcreated by@ansm and Health Insurance, publishes a study on the characteristics associated with the residual risk of a severe form of Covid-19 after a complete vaccination schedule in France. https://t.co/ZWK7C0gQji
— Health Insurance (@Assur_Maladie) February 11, 2022
People followed for more than two months
To carry out this research, the researchers based themselves on a sample of 28 million people, having a complete vaccination schedule on July 31, 2021. They were followed from the 14th day following the second dose of vaccine, or 14th day after the first in case of prior infection and for an average duration of 80 days. During this period, 5,345 people were hospitalized, or 19 per 100,000, and 996 died in hospital due to Covid-19.
The greater the number of comorbidities, the greater the risk
“The risks of hospitalization and hospital death for Covid-19 were associated with age, for example, compared to people aged 45-54, those aged 85-89 had a 4 times higher risk of being hospitalized for Covid-19 and 38 times higher to die“, say the authors of the study. The second risk factor is gender: men had a 1.6 times higher risk of hospitalization, and twice as high for death. The scientists also note that people hospitalized or who died of Covid-19, despite vaccination, generally had comorbidities: “IVaccinated patients with a single comorbidity were twice as likely to be hospitalized for Covid-19 compared to vaccinated patients with no identified comorbidity. The higher the number of comorbidities, the higher the risk. Thus, people with two comorbidities had a three times higher risk of hospitalization, five times higher for those with three, seven times higher for those with four comorbidities. Vaccinated patients with more than five comorbidities had a 13 times higher risk of hospitalization.
Place of residence, another risk indicator
The authors also note that the social situation of vaccinated people has an impact on their risk of developing a serious form. “People residing in the most disadvantaged municipalities had a 1.3 times higher risk of hospitalization and a 1.5 times higher risk of death than those from the most advantaged municipalities.“, is it indicated in the study. For the authors, it is important to put in place additional preventive measures for vaccinated people exposed to these risk factors.
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