Numerous studies have highlighted genes may play a role in the development of autism, and autism spectrum disorders (ASD) in general.
However, it could be much more complex, and it is not just these few genes that would lead to this condition.
An American study published in the scientific journal Molecular Systems Biologyhas identified an entire network of molecules made up of proteins that may contribute to autism.
We all have a genome, made up of all of our genes. These genes allow the body to obtain proteins, which make our body work. But within each cell type (heart cells, epidermis cells, neurons, etc.), only part of the genome is activated, depending on the missions with which the cells are responsible. Thus, genes activated in liver cells may be “silent” in skin cells.
Investigate the proteins that arise from the genome
Thus, for the study, the researchers were not only interested in the genome, but looked into the expression of genes, and the proteins that determine them. flow, in patients withautism. They thus identified a network of protein interactions, which proved to be linked to autism, after analyzes carried out on 525 patients.
Scientists have also discovered that brain cells that help protect neurons play an important role in autism. Their incorrect operation would not allow proper circulation of nerve signals between the right and left hemispheres of the brain.
“Our analysis delineates a natural network involved in autism, and reveals new genes and molecules responsible for this condition, explain the authors of the study in their publication. This improves our understanding of the molecular pathology of autism. HAS”
In addition to contributing to knowledge in the field of autism spectrum disorders, this study offers a new approach to address diseases that are still poorly understood.
“Our study highlights the importance of building molecular integration models to study complex human diseases,” says Professor Michael Snyder, lead author of the study. The use of biological networks has allowed us to superimpose the genetic mutations of autism on molecular pathways. This provides a framework for updating molecular networks for other diseases. HAS”
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