May 9, 2001 – It has been known for 30 years that vitamin B12 deficiency is a common problem in old age and it has already been highlighted (Carmel R, 2000) that the cognitive functions of people with Alzheimer’s and vitamin B12 deficient could be improved by supplementation with B12.
However, a Swedish study has just clearly established that people with a deficiency in folate (B9) or vitamin B12 run an increased risk of developing Alzheimer’s disease.
The Swedish study followed for 3 years a cohort of 370 people aged over 75 and untreated for folate or B12 deficiency. During this time, 78 participants developed some form of senile dementia. However, of these 78 people, 46 had a deficiency in vitamin B12 or in folate.
The study authors believe that the deficiencies observed influence neurotransmitters (which are involved in cognitive processes) or levels of homocysteine, an amino acid that has a neurotoxic effect and is also a predictor of heart disease. However, vitamins B12 and B9 are involved in the control of homocysteine levels. The researchers, who show the greatest restraint, conclude that monitoring the levels of B12 and folate may be relevant in preventing the onset of Alzheimer’s disease.
Vitamin B12 supplementation, which is sometimes used empirically in the treatment of Alzheimer’s disease, finds here one of the first confirmations of its therapeutic relevance.
HealthPassport.net
Wang HX, Wahlin AA, Basun H, Fastbom J, Winblad B, Fratiglioni L. Vitamin B (12) and folate in relation to the development of Alzheimer’s disease. Neurology. 2001 May 8; 56 (9): 1188-1194.B12 supplements may aid cognitive function in the elderly (Reuters Health, August 31, 2000)
