Certain biomarkers may help predict the risk of chronic kidney disease in hospitalized patients with acute kidney injury.
- Seven urinary biomarkers and two plasma biomarkers were measured.
- Each gap increase in biomarker change KIM-1 and MCP-1 in urine and TNFRI in plasma was associated with a two- to three-fold increased risk of chronic kidney disease.
- The rise in the urinary biomarker UMOD was linked to a 40% reduction in the risk of chronic kidney disease.
They are bean-shaped and located behind the abdomen. Every 30 minutes, the kidneys filter the blood to eliminate waste, evacuate it in the urine and keep only the substances useful for the proper functioning of the body. Kidney failure is when both organs stop working properly, which can lead to a buildup of waste products and fluids in the body.
Acute renal failure: nearly 20% of hospitalized patients develop it
“About 20% of hospitalized adults develop acute kidney injury and have a three to eight times increased risk of developing chronic kidney disease later in life. The incidence of acute kidney injury in hospital continues to rise. increase, which is why we sought to understand how and why acute renal failure progresses to chronic renal failure, and whether monitoring these patients over time can give us clues about the evolution of the insufficiency kidney”, said Chirag Parikh, director of the division of nephrology at Johns Hopkins University School of Medicine, in a statement.
In a study published in the journal Journal of Clinical Investigation, his team wanted to determine the links between changes in urine and blood biomarkers and the progression of kidney disease after acute kidney injury. For this, they recruited 656 adults hospitalized because of acute renal failure. The scientists measured seven urinary biomarkers and two plasma biomarkers of kidney damage, inflammation and tubular health at multiple time points, from diagnosis up to one year after the onset of acute kidney injury.
Chronic kidney disease: urine and blood biomarkers help predict risk
“After 4.3 years, 106 and 52 participants developed incident chronic renal failure and progressive chronic renal failure, respectively,” can we read in the searches. The researchers found that each incremental increase in change in the biomarker KIM-1 and MCP-1 in urine and TNFRI in plasma between the start of the study and one year later was associated with a two to three risk times higher for chronic kidney disease.
“Long-lasting tissue damage and inflammation, as well as slower recovery of tubular health, are associated with a higher risk of kidney disease progression,” noted the authors. However, they also observed that the increase in the urinary biomarker UMOD was associated with a 40% reduction in the risk of chronic kidney disease.
According to the team, these results could help doctors better understand whether the body heals properly after kidney injury and possibly prevent progression from acute kidney failure to chronic kidney failure. Chirag Parikh emphasizes the need for further research on these ongoing biological processes to better understand the transition from acute kidney failure to chronic kidney failure.
