Regardless of the body mass index and traditional risk factors, high variability in body weight is linked to an increased risk of kidney events in people with type 1 diabetes.
- In the event of type 1 diabetes, larger weight fluctuations are associated with a 40 % drop in the glomerular filtration rate, that is to say the ability of the kidneys to filter blood toxins.
- In addition, they increase the risk of albuminuria, a condition in which the protein albumin is abnormally present in the urine.
- According to researchers, strategies to reduce weight in people with type 1 diabetes should focus on promoting long -term weight maintenance.
After having a diet, the Yoyo effect can occur. This is the process that starts with rapid weight loss, but which then leads to a weight recovery as fast, or even more than in relation to the starting level. In adults with type 1 diabetes, the latter is not without consequences since the Yoyo effect can increase the risk of kidney disease. This was recently revealed by a study published in the journal The Journal of Clinical Endocrinology & Metabolism.
A high variability of the weight is linked to a 40 % drop in kidney capacity to filter blood toxins
In order to achieve this conclusion, researchers from the Bordeaux University Hospital Center have focused on the main index making it possible to identify the food diagrams in Yoyo, which is known as “variability independent of the average” (VIM) . It measures fluctuations above and below the average body weight of a person. By analyzing the data on the weight fluctuations of previous research on diabetes, the team examined six criteria for declining kidney function and progression to a chronic kidney disease in 1,432 participants. Their main criterion was the “estimated glomerular filtration rate”, which measures the ability of the kidneys to filter blood toxins.
Volunteers with larger weight fluctuations experienced a 40 % drop in the estimated glomerular filtration rate compared to the basic values. People with larger weight fluctuations were also more likely to present a moderate and severe increase in albuminuria, a condition in which the protein albumin is abnormally present in the urine. Most significant quantities occur in the urine of patients with kidney disease. “Similar results have been confirmed by the other indications examined”, Can we read in the study.
Type 1 diabetes: “Weight stability can have a positive impact on health results”
Although the pathophysiological mechanisms associating weight changes with renal risk are not yet fully understood, the authors suggest that insulin therapy, necessary to treat type 1 diabetes, can contribute to weight fluctuations. Other researchers have hypothesized that the change in weight can cause additional pressure on the heart and contribute to renal and vascular lesions. “Strategies aimed at reducing weight in people with type 1 diabetes should focus on promoting long -term weight maintenance, because weight stability can have a positive impact on health results”, concluded French scientists.
