Following clinical trials, the vaccines have shown particularly high efficacy ratesaround 95% to limit serious forms.
But with the progress of vaccination campaigns, we are beginning to have a step back to verify this effectiveness in real life. According to one study Epipharusconducted with health insurance with 4 million people including 1.4 million vaccinated (mostly with Pfizer) “the impact of vaccination is major”.
Indeed, the first results show that the risk of a severe form of Covid-19 decreases by 87% in people over 75, 7 days after the injection of the 2nd dose. This means they are 9 times less likely to be hospitalized for Covid-19 than unvaccinated people over 75.
This strong efficacy is not immediate, according to this study:
- D1 : from the first injection, the protection increases to 59%.
- D1 to D13 : then, the first two weeks after the injection, the protection remains stable with a very slight decrease, around 56%.
- D14 to D41: lon the other hand, risk reduction is less between the 14th day after the first dose and the administration of the second dose (at 42 days): the rate is then much lower (33%).
- After D42 : the injection of the second dose boosts the protection, which climbs to 86% and even 87%, seven days after this second injection (D49).
This suggests that one should not feel protected after the first dose. It is the complete two-dose regimen that provides optimal protection.
In addition, according to this study, the reduction in risk after 7 days post-second dose is more marked in people aged under 85 compared to those aged 85 and over.
The Importance of Full Vaccination in Adults
Other countries have already conducted studies on the real-life effectiveness of vaccines: the largest comes from Israel, champion of vaccination, with Pfizer/BioNTech.
In early May, vaccination data obtained in real life (between January 24 and April 3)in Israelel have been published in the medical journal The Lancet. As of April 3, 72% of those over 16 and 90% of those over 65 had received their two doses of the Pfizer vaccine.
Conclusion ? The study confirms that THE Pfizer-BioNTech vaccineEast more than 95% effective against infectionsTo over 97% against hospitalizations and deaths.
However, the study shows a noticeable decrease in efficacy in the people Who received only one of the two doses: 57.7% against infection, 75.7% against hospitalizations and 77% against deaths in those over 16 years of age. That“shows the importance of full vaccination in adults”, comment authors.
Finally, remember that even for vaccinated people, the application of barrier gestures and the wearing of a mask remain necessary.
Sources:
- Efficacy of the Pfizer vaccine, EMA report.
- Impact of vaccination in Israel, The Lancet, May 5, 2021.
- Estimation of the impact of vaccination in people aged 75 and over on the risk of severe forms of Covid-19 in France, ANSM, May 2021.
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