Finnish researchers have recently discovered a new type of genetic mutation that alters behavior, reduces fear, anxiety and increases social interaction.
You are too much anguish Where too shy ? Finnish researchers have made a discovery that may one day solve your problem. Indeed, the latter have discovered a new type of gene mutation, which reduces fear, anxiety and increases social interactions. They used technology to remove the P4h-tm gene from the mouse genome and then observed an unexpected change in the behavior of the mice: they showed remarkable courage. The results of the study are published in the journal Neuropharmacology.
Beneficial effects on mice…
The researchers performed a battery of behavioral tests, including a new type of panic reaction assessment test. The mice were placed in an airtight box filled with air and 10% carbon dioxide. A high concentration of carbon dioxide leads to a sensation similar to the feeling of suffocation when a patient experiences a panic attack. Mice without the P4h-tm gene reacted much less than the others. In addition, the researchers found that these mice came into more contact with others and felt less fear and anxiety.anxiety.
… But risks for humans
The P4h-tm gene has a role in the transcription of the P4H-TM protein. The latter in turn plays a central role in cellular adaptation to a sudden lack of oxygen. However, we still know little about this protein, despite years of intensive research.
“Our results are really interesting, but according to a recent international study, […] we know that deficiency of the P4H-tm gene leads to severe developmental defects in humans,” says Professor Heikki Tanila, from the University of Eastern Finland. He continues: “However, in the light of current knowledge, we cannot say whether these adverse effects result from embryonic development or whether they would also manifest if the function of the P4H-TM protein were inhibited in adulthood.”
Although we are far from the therapeutic application to humans, this discovery could lead to the development of new drugs against anxiety and depression. According to the World Health Organization (WHO), nearly 300 million people worldwide suffer from anxiety issues. Same number for depression.
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