the polycystic ovary syndrome(PCOS) affects about one in 10 women. This syndrome impairs the growth of ovarian follicles and interferes with egg production, making it the most common of the disorders of the ovary.female infertility. Although we can now diagnose the disease, its cause is still unknown. However, researchers from Inserm and the University of Lille believe that this syndrome is caused by overexcitation of brain neurons.
“The culprit: a hormone produced by ovaries, called anti-Müllerian hormone (AMH), which is overproduced in women with PCOS “ emphasize the researchers.
Our work in mice shows that PCOS not only affects the ovaries but also modifies the activity of brain neurons located in the hypothalamus and responsible for controlling reproduction. In patients with PCOS, the anti-Müllerian hormone has a blood level two to three times higher, directly related to the severity of the disease.
These results appeared in Nature Medicine open the way to new avenues for the development of a treatment.
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