Researchers have developed a urinary test to detect aggressive forms of prostate cancer, avoiding invasive procedures.
- Researchers have developed a urinary test to detect cancers of the high -grade prostate.
- He is able to spot 18 genes linked to this aggressive form of cancer.
- It could be made at home, without requiring prior rectal rectal.
Prostate cancer screening is complex. “”We do not know how to distinguish the cancers of the prostate which will become aggressive and which must be treated, cancers which will remain “latent”, that is to say which will not reveal themselves or which will evolve very slowly (often on more 15 years) and which do not require treatment “indicates theHealth insurance. In addition, screening is carried out thanks to three main exams: blood tests, MRI and biopsies, some of which can be invasive.
But, this could soon change thanks to a urinary test developed by a team from the Center against Health Rogel Cancer from the University of Michigan. In Journal of Urologythe researchers explain that they have developed a tool to identify characteristic genes of the aggressive forms of prostate cancer in the urine.
Detect high -grade prostate cancers thanks to urine
As a preamble to their work, American scientists recall that prostate cancers are classified according to their Gleason grade. “”Those with Gleason 3 + 4 = 7, or group 2 of grade 2, or more are more likely to grow and cause damage compared to prostate cancers Gleason 6 or group 1 of grade 1, which are considered non -aggressive “”they say. The urine test they created, called MyProstatesCore 2.0, or MPS2, examines 18 different genes linked to high -grade prostate cancer. In a previous test, they have shown that it can identify Group 2 cancers of Grade 2, which avoids unnecessary biopsies. However, it implies previously carrying out a rectal touch. “”The process requires the prostate to be compressed, causing the release of cellular debris in a urine sample that the patient provides after the rectal examination“, Indicates Ganesh S. Palapattu, professor of urology and co-author of the study. However, this exam may be uncomfortable.
Prostate cancer: a future review of home?
For this reason, researchers at the University of Michigan have developed a testable home test. Using urine samples of 266 men who have not undergone a rectal exam, they found that the test could detect 94 % of group 2 or more group cancers, and that it was more sensitive than the blood tests. According to the team, the use of MPS2 would have avoided up to 53 % of unnecessary biopsies. “”These results show that MPS2 is promising as a home testestimates Ganesh S. Palapattu. MPS2 could potentially improve the health of our patients by avoiding overdiagnosis and over-treatment and allowing us to focus on those who are most likely to have aggressive cancers. “
