These are the two nonsteroidal anti-inflammatory drugs (NSAIDs) without precautions for fever with headache or throat. However, the French Medicines and Health Products Safety Agency (ANSM) warns:ibuprofen (Nurofen, Advil, Upfen Antarene) and the ketoprofen (Profenid, Toprec, Ketum) could promote serious complications. According to a survey, published this Thursday, April 18, 337 cases of infectious complications including 32 deaths were listed for ibuprofen and 46 cases including ten deaths with ké © toprofen, from 2000 to 2018. Ã ?? in the light of these data, the drug gendarme thus calls for caution.
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are the subject of #pharmacovigilance involving serious infectious complications
The survey suggests an aggravating role of #AINS in case of infection#ibuprofen# ketoprofen
To???? info https://t.co/A4mJxiExLTpic.twitter.com/7TncvalTpT
– ANSM (@ansm) April 18, 2019
Severe infections
More in detail, serious strep and pneumococcal complications have been identified in people, children as well as adults, not presenting a priori any risk factor before taking NSAIDs. And this, even after short durations of treatment (2 to 3 days), or combined with antibiotic therapy.
After ingesting ibuprofen or ketoprofen, they suffered from severe infections of the skin and soft tissues (dermohypoderma, necrosing fasciitis), sepsis , pleuropulmonary infections (pneumonia complicated by abscess, pleurisy), neurological (empyema, cerebral abscess) or ENT (cervico-facial cellulitis, mediastinitis) , At the origin of hospitalizations, of which, even of death.
Already, previous studies had shown the cardiovascular risk or danger to the fetus from taking ibuprofen.
Favor paracetamol
“The conclusions of this investigation suggest the aggravating role of these NSAIDs in the event of infection”, in particular those due to streptococcus, notes the ANSM. She says she shared these results with her European counterparts.
The agency also invites to privilege the paracetamol in case of pain and fever, especially during common infections (angina, nasopharyngitis, ear infection, cough, lung infection, skin lesion or chickenpox), especially in cases of self-medication. The minimum dose and the shortest duration should be preferred, i.e. “No more than 3 days in case of fever and 5 days in case of pain”. In case of persistent symptoms, do not hesitate to talk to your pharmacist or doctor.
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