Urolithiasis, which causes kidney stones, is a disease characterized by the formation of stones in the kidneys or ureters that are too large to pass through the bladder. Without great seriousness if they are treated, the kidney stones can nevertheless be at the origin of violent pains, known as “renal colic”, by obstructing the ways of the urinary tract. So far, the only way to effectively prevent these stones is to follow a strict diet; low in salt, protein, and drinking water regularly.
When the stones are too large to be evacuated, heavier methods should be considered. Extracorporeal lithotripsy allows the stone to be reduced to small fragments via shock waves. In rare cases, percutaneous nephrolithotomy may be considered, it consists of inserting an endoscope into the kidney, then fragmenting the stone with ultrasound in order to collect and evacuate the debris.
Finally, it is always possible to remove stones surgically using instruments or lasers.
According to researchers at the University of Houston, hydroxycitric acid (HCA), a chemical compound extractable from certain tropical fruits, could be the basis of a new treatment in the prevention of kidney stones due to the formation of these. calcium oxalate crystals (80% of cases).
Published in the journal Nature, their study shows that, under certain conditions, HCA is able to prevent the growth of calcium oxalates and to dissolve them effectively.
Encouraging first tests
Scientists also sought to determine whether the treatment could have long-term negative effects by testing for HCA in seven human subjects. Study author Professor Jeffrey Rimer says these early findings helped them lay the foundation for designing an effective treatment. However, he adds that further clinical trials are needed.
“Our early research looks very promising. If it works in vivo, like our laboratory tests, HCA has the potential to reduce the number of people with chronic kidney stones.”
In France, about one in ten people would be affected by the disease. Hypertension, diabetes or obesity are additional risk factors. After a first kidney stone, the risk of recurrence within ten years is estimated at nearly 70%.
At the moment, simple dietary rules limit the risk of stone formation. Thus, do not over-salt your food, drink at least two liters of liquid per day, practice regular physical activity and avoid a diet that is too rich are particularly recommended.
Note that it is possible to enjoy the benefits of HCA by drinking … lemonade, recommended by doctors in case of kidney stones!
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